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“When after the first controlled study with our arthritis patients more than 90% reported dramatic improvements in movement and pain-free activity we considered it a fluke.  After the second trial when we had the same results we considered it a miracle.”

Dr. S Connolly, San Diego Institute of Chiropractic Medicine.

 

 

herbal clinical trials

“I’m amazed at the results that we’re finding in our patients.  Its literally the most amazing thing I’ve seen in 15 years of practice. . . we’re seeing total resolution of symptoms” Dr. Michael Gray

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"Everyone we have used the product on has had tremendous success in reducing the pain, swelling and stiffness of arthritis.One of the major advantages of the product that we've noticed, is that patients are no longer having to take prescription strength, anti-inflammatory medication or the over-the counter, so they're saving the expense of the products and they're not having the side effects of these medications.. the upset stomach the burning stomach, loss of appetite,the hair loss.The liver is involved in processing these drugs and patients are worried about these side effects and as they are no longer taking the medications they dont have the potential side effects anymore".Dr. Manley

 

 

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channel 9 australia - arthritis formula is amazing doctors-nature medic formula

STUDY

Hugh A. Gemmell, DC, EdD,a Bert H. Jacobson, EdD,b and Brad M. Hayes, DCc

 

ABSTRACT

Objective: To compare the efficacy of an herbal ointment to a sham ointment for relieving pain and stiffness

associated with osteoarthritis of the hand and knee.

 

Method: Single-blind, randomized controlled clinical trial conducted in 3 chiropractic medicine practices.

Selection of subjects with osteoarthritis of the hand or knee was based on the criteria developed by the American College of Rheumatology. Subjects applied the herbal ointment to the affected joint(s) for 42 consecutive days

 

Results: Thirty subjects completed the study (15 active and 15 sham). Significant differences in pain (P  .003)

and stiffness (P  .0008) were found between the first 21 days of application and the last 21 days of application for

the experimental group but not for the sham group.

 

Conclusion: An herbal ointment showed significant improvement in pain and stiffness for patients with hand and

knee osteoarthritis who applied the ointment to the affected joint(s) for 42 consecutive days.

 

In vivo wound healing effects of Symphytum officinale L. leaves extract in different topical formulations.

Araújo LU1, Reis PG, Barbosa LC, Saúde-Guimarães DA, Grabe-Guimarães A, Mosqueira VC, Carneiro CM, Silva-Barcellos NM.

Author information

1Departamento de Farmácia, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Brasil.

Abstract

The present work evaluates wound healing activity of leaves extracts of Symphytum officinale L. (comfrey) incorporated in three pharmaceutical formulations. Wound healing activity of comfrey was determined by qualitative and quantitative histological analysis of open wound in rat model, using allantoin as positive control. Three topical formulations, carbomer gel, glycero-alcoholic solution and O/W emulsion (soft lotion) were compared. The histological analysis of the healing process shows significant differences in treatment, particularly on its intensity and rate. The results indicate that emulsion containing both extracts, commercial and prepared, induced the largest and furthest repair of damaged tissue. This could be evidenced from day 3 to 28 by increase in collagen deposition from 40% to 240% and reduction on cellular inflammatory infiltrate from 3% to 46%. However, 8% prepared extract in emulsion presented the best efficacy. This work clearly demonstrates that comfrey leaves have a wound healing activity. The O/W emulsion showed to be the vehicle most effective to induce healing activity, particularly with extracts obtained from comfrey leaves collected in Minas Gerais state in Brazil. It shows the best efficacy to control the inflammatory process and to induce collagen deposition at 8% concentration.

A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis.

Myers SP1, O'Connor J, Fitton JH, Brooks L, Rolfe M, Connellan P, Wohlmuth H, Cheras PA, Morris C.

Author information

BACKGROUND:

Isolated fucoidans from brown marine algae have been shown to have a range of anti-inflammatory effects.

PURPOSE:

This present study tested a Maritech((R)) extract formulation, containing a blend of extracts from three different species of brown algae, plus nutrients in an open label combined phase I and II pilot scale study to determine both acute safety and efficacy in osteoarthritis of the knee.

PATIENTS AND METHODS:

Participants (n = 12, five females [mean age, 62 +/- 11.06 years] and seven males [mean age, 57.14 +/- 9.20 years]) with a confirmed diagnosis of osteoarthritis of the knee were randomized to either 100 mg (n = 5) or 1000 mg (n = 7) of a Maritech((R)) extract formulation per day. The formulation contained Maritech((R)) seaweed extract containing Fucus vesiculosis (85% w/w), Macrocystis pyrifera (10% w/w) and Laminaria japonica (5% w/w) plus vitamin B6, zinc and manganese. Primary outcome was the average comprehensive arthritis test (COAT) score which is comprised of four sub-scales: pain, stiffness, difficulty with physical activity and overall symptom severity measured weekly. Safety measures included full blood count, serum lipids, liver function tests, urea, creatinine and electrolytes determined at baseline and week 12. All adverse events were recorded.

RESULTS:

Eleven participants completed 12 weeks and one completed 10 weeks of the study. Using a multilevel linear model, the average COAT score was reduced by 18% for the 100 mg treatment and 52% for the 1000 mg dose at the end of the study. There was a clear dose response effect seen between the two treatments (P

CONCLUSION:

The seaweed extract nutrient complex when taken orally over twelve weeks decreased the symptoms of osteoarthritis in a dose-dependent manner. It was demonstrated to be safe to use over the study period at the doses tested. The efficacy of the preparation now needs to be demonstrated in a phase III randomized controlled trial (RCT). AUSTRALIAN AND NEW ZEALAND CLINICAL TRIALS REGISTER: ACTRN12607000229471.

Natural products as a gold mine for arthritis treatment.

Khanna D1, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB.

Author information

Abstract

Arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1beta) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase), together with the expression of adhesion molecules and matrix metalloproteinases, and hyperproliferation of synovial fibroblasts. All of these factors are regulated by the activation of the transcription factor nuclear factor-kappaB. Thus, agents that suppress the expression of tumour necrosis factor-alpha, interleukin-1beta, cyclooxygenase-2, lipooxygenase, matrix metalloproteinases or adhesion molecules, or suppress the activation of NF-kappaB, all have potential for the treatment of arthritis. Numerous agents derived from plants can suppress these cell signaling intermediates, including curcumin (from turmeric), resveratrol (red grapes, cranberries and peanuts), tea polyphenols, genistein (soy), quercetin ( oakbark & aloe vera) , silymarin (artichoke), guggulsterone (guggul), boswellic acid boswellia nolides (ashwagandha). Indeed, several preclinical and clinical studies suggest that these agents have potential for arthritis treatment. Although gold compounds are no longer employed for the treatment of arthritis, the large number of inexpensive natural products that can modulate inflammatory responses, but lack side effects, constitute 'goldmines' for the treatment of arthritis.

Aqueous extracts of Cimicifuga racemosa and phenolcarboxylic constituents inhibit production of proinflammatory cytokines in LPS-stimulated human whole blood.

Schmid D1, Woehs F, Svoboda M, Thalhammer T, Chiba P, Moeslinger T.

Author information

Abstract

Cimicifuga racemosa (black cohosh) is commonly used in traditional medicines as treatment for menopausal symptoms and as an antiinflammatory remedy. To clarify the mechanism of action and active principle for the antiinflammatory action, the effects of aqueous C. racemosa root extracts (CRE) and its major constituents on the release of the proinflammatory cytokines IL-6, TNF-alpha, IFN-gamma, and the chemokine IL-8 were investigated in lipopolysaccharide (LPS)-stimulated whole blood of healthy volunteers. CRE (3 microg/microL and 6 microg/microL) reduced LPS-induced release of IL-6 and TNF-alpha in a concentration- and time-dependent manner and almost completely blocked release of IFN-gamma into the plasma supernatant. Except for IFN-gamma, these effects were attenuated at longer incubation periods. IL-8 secretion was stimulated by CRE. As shown by quantitative real-time RT-PCR, effects on cytokines were based on preceding changes in mRNA levels except for IL-8. According to their content in CRE, the phenolcarboxylic compounds caffeic acid, ferulic acid, and isoferulic acid, as well as the triterpene glycosides 23-epi-26-deoxyactein and cimigenol-3-O-xyloside, were tested at representative concentrations. Among these, isoferulic acid was the prominent active principle in CRE, responsible for the observed inhibition of IL-6, TNF-alpha, and IFN-gamma, but not for IL-8 stimulation. The effect of this compound may explain the antiinflammatory activities of CRE and its beneficial actions in rheumatism and other inflammatory diseases.

Ginkgolide B reduces inflammatory protein expression in oxidized low-density lipoprotein-stimulated human vascular endothelial cells.

Zhang S1, Chen B, Wu W, Bao L, Qi R.

Author information

Abstract

Ginkgolide B is a herbal constituent extracted from leaves of the ginkgo biloba tree. Previous studies have shown that ginkgolide B is a specific platelet activating factor (PAF) receptor antagonist, and it suppresses PAF-mediated platelet activation via competitive binding. In this study, the effect of ginkgolide B on nicotinamide adenine dinucleotide phosphate oxidase and other inflammatory proteins in ox-LDL (low-density lipoprotein)-stimulated human vascular endothelial cells was investigated. Another PAF receptor antagonist CV3988 was employed to compare with ginkgolide B in this study. Our results show that the enhancement of Nox4 expression and reactive oxygen species generation was attenuated by ginkgolide B in cells treated with ox-LDL but not with CV3988. Increases in monocyte chemoattractant protein-1 and intercellular adhesion molecule 1 expression induced by ox-LDL, however, were inhibited by both ginkgolide B and CV3988. The translocation of NF-kappaB p65 (NF-B) into the nucleus was inhibited by both ginkgolide B and CV3988. In conclusion, both ginkgolide B and CV3988 can inhibit the expression of inflammatory proteins by blocking NF-B translocation. It seems that ginkgolide B possesses some pharmacological action on intracellular oxidative stress in association with the downregulation of Nox4 expression.

what the physicians are saying

The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.

    The amino acids in Aloe vera are the building blocks of protein and influence our brain function.  Every one of  the bodies required essential amino acids are available in Aloe vera and they include isoleucine, leucine, lysine, methionine, phenylalanine, threonine, valine,and tryptophan. Some of the other non-essential amino acids found in Aloe vera include alanine, arginine, asparagine, cysteine, glutamic acid, glycine, histidine, proline, serine, tyrosine, glutamine, and aspartic acid.

   

    Located in the sap of the leaves you will find twelve anthraquinones, a phenolic compound  that breaks up residue, pus and lifeless cells,  and flushes out material from wounds and ulcers.

 

         Enzymes act as biochemical catalysts that break down the proteins we eat into amino acids.  The main enzymes found in Aloe vera include Amylase (breaks down sugars and starches), Bradykinase (stimulates immune system, analgesic, anti-inflammatory), Catalase (prevents accumulation of water in the body), Cellulase (aids digestion - cellulose), Lipase (aids digestion - fats), Oxidase, Alkaline Phosphatase, Proteolytiase (hydrolyses proteins into their constituent elements), Creatine Phosphokinase (aids metabolism), and Carboxypeptidase.

 

   The key to fueling enzymes is the vitamins and minerals we take in.  Aloe vera, an anti-oxidant rich plant, contains vitamins such as A, C, and E plus the minerals, zinc, and selenium. Anti-oxidants help boost the immune system and combat free radicals in the body.

 

    It also contains Vitamins B1, B2, B3, B5, B6, and B12 along with choline, calcium (teeth and bone formation, , magnesium (strengthens teeth and bones),manganese (activates enzymes, builds healthy bones, nerves and tissues)

    Additional minerals found in Aloe vera include copper potassium, phosphorus (helps build bones and teeth, and sodium .

 

     Another component of Aloe vera consists of the lignins, a major structural material of cellulose content, that allows for penetrative properties.  Aloe vera can soak into the skin up to seven layers deep.  Lignins penetrate the toughened areas of the skin being beneficial for skin problems such as eczema and psoriasis. Also includes monosaccharides and polysaccharides.

Transdermal medicine delivers medications to the exact site of injury or pain. Transdermal medicine is ideal for pain management as well as sports and pediatric medicine. Transdermal or topical applications like Nature Medic deliver a range of nutrients through an  absorption process that allows for quick delivery into the blood stream. Studies in this field also show that in many cases there is greater nutrient absorption because vitamins and minerals are not required to go through the gastro intestinal or digestive tract.

 

Dr. Mark Brown. Chiropractor